Pharmacodynamics studies on ricobendazole in male rats

The present study was conducted to study the effect of ricobendazole on male fertility, as well as its effects on the liver and kidney functions tests, some hematological parameters and histopathological changes. Forty-five mature male albino rats were used and divided into 3 equal groups. The first group was kept as control and subcutaneously injected with proplyene glycol [2 ml /kg b.wt.]. The second group was received a single subcutaneous injection of ricobendazole at a dose of 7.5 mg/kg bwt. The third group was subcutaneously injected with 7.5 mg / kg bwt twice within 3 weeks interval. The obtained results showed that administration of ricobendazole as single or repeated dose induced a variety of side effects on male reproduction as reduction of testes, epididymis, and accessory sex organs weights and change in sperm characters; decease of sperm count and motility, and increase in sperm abnormalities. liver functions test values such as Serum alanine aminotransferase [ALT] and aspartate aminotransferase [AST] and alkaline phosphatase [AlP] were significantly increased. Moreover, administration of ricobendazole induced histopathological alterations in reproductive organs, liver and kidney. The adverse effects of ricobendazole was more pronounced in repeated dose group. Therefore, caution is required when using repeated doses of ricobendazole

Adverse effects of marbofloxacin in male rats

The present work was a trial to study the effect of marbofloxacin on the reproductive system in male Albino rats. Moreover, some biochemical parameters were also examined. Fourty five mature male Albino rats weighing from 140- 180 gm each of 4-5 month old were used in this study. The animals were divided into 3 equal groups each of 15 rats. The first and second groups were injected I/M for 5 consecutive days with marbofloxacin at the dose level of 7.2 mg/ Kg B.Wt and 14.4 mg/ Kg B.Wt. respectively. The third group was kept as control and injected I/M with 0.3 mL saline /rat for 5 consecutive days. The obtained results showed that administration of marbofloxacin induced a variety of adverse effects. These are represented by certain fertility troubles as reduction of testes, epididymis and accessory sex organs weights, changes in sperm characters [decrease of sperm count and motility] and decrease of serum testosterone level. Moreover, the liver and kidney functions were significantly affected. Therefore, caution is required when using large doses of the drug of marbofloxacin due to its adverse effect on the sperm characters, liver and kidneys

Effects of ceftriaxone on reproductive and biochemical aspects of male rats

The present work was a trial to study the effect of ceftriaxone on the reproductive system in male Albino rats. Moreover, some biochemical parameters were also investigated. Fourty-five mature male albino rats weighing from 120 -160 g each of 4-5 month old were used in this study. The animals were divided into 3 equal groups, each of 15 rats. The first and second groups were injected I/M for 5 consecutive days with ceftriaxone at the dose level of 75 mg/kg B.wt. and 300 mg/kg B.wt. respectively. The third group was kept as control and injected I/M with 0.3 ml saline/ rat for 5 consecutive days. The obtained results showed that administration of ceftriaxone induced a variety of side effects. These are represented by reduction of testes, epididymis and accessory sex organ weight, changes in sperm characters [decrease of sperm count and motility] and increase of sperm abnormalities. Moreover, the liver functions were significantly affected. Therefore, caution is required when using large doses of ceftriaxone due to its toxicity to reproductive organs as well as its increasing effect on liver enzymes

Reproductive troubles induced by ivermectin or triclabendazole and their combinations in male rats

The present study was carried out to evaluate the effect of administration of ivermectin and / or its interaction with triclabendazole on some reproductive organs weight, epididymal sperm characters and serum testosterone level in mature male rats. Sixty mature male rats were divided equally into 4 groups each of 15 rats. The first group received s.c. ivermectin [0.56 mg/kg. b.wt.], the second group received orally triclabendazole [35mg/kg b.wt.], the third group received ivermectin plus triclabendazole as previously mentioned and the fourth group received saline [control group]. After 31 days from drugs administration, the drugs were repeated to all groups. The obtained results showed that administration of two doses of ivermectin, triclabendazole or both together induced a variety of adverse effects. These are represented by certain fertility troubles as reduction of some reproductive organs weight, changes in semen characters [decrease of sperm count and motility and increase of total sperm abnormalities, as well as a decrease in serum testosterone level. It could be concluded that the most harmful effect on male fertility induced by a coadministration of ivermectin and triclabendazole than giving each drug alone